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Greater Occipital Nerve Block for Migraine With Medication Overuse Headache

RecruitingNAAges 18 Years - 80 YearsAllMahidol University
NCT07568496 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Migraine is among the leading causes of disability worldwide. Inappropriate use of acute medications in the setting of primary headache, particularly migraine can result in a debilitating condition known as medication overuse headache (MOH). Treatment of MOH is challenging and the primary therapeutic approach is reducing painkillers which helps decrease the number of headache days. As a part of the detoxification process to discontinue acute medications, bridging therapy is often needed to reduce withdrawal headache. Currently, there are data supporting the use of greater occipital nerve block as a preventive treatment in chronic migraine, but no placebo-controlled trial has evaluated the efficacy of greater occipital nerve block in MOH. Therefore, this research aims to demonstrate the efficacy of greater occipital nerve block in detoxification of migraine patients with MOH. Patients wil

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients who have a diagnosis of migraine with medication overuse headache according to ICHD-3 criteria confirmed by a neurologist * Female patients will be screened for pregnancy planning and married female patients must undergo a urine pregnancy test Exclusion Criteria: * Patients who have other types of headache disorders other than migraine * Patients who have a previous history of allergy to corticosteroid or lidocaine * Patients who had previous skull surgery * Pregnant women * Patients with a history of uncontrolled depression, or psychosis * Patients who get or plan to get CGRP-targeted therapies or botulinum toxin injection * Patients with an increased risk of bleeding or underlying bleeding disorders
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What it tests

  • Lidocaine 2% and Methylprednisolone 80 mg
  • Placebo
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Where

3 sites
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, Thailand
Faculty of Medicine, Prince of Songkla University
Hat Yai, Thailand
Faculty of Medicine, Chiang Mai University
Chiang Mai, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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