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Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery

RecruitingNAAges 18 Years - 65 YearsAllG.Gennimatas General Hospital
NCT07568938 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery. The main question it aims to answer : -Will there be a difference in the perioperative stress between patients receiving OFA with and without desflurane? Participants will undergoing sleeve gastrectomy or gastric by pass, will be administered OFA with and without desflurane and blood tests (cortisole, ACTH,dopamine, PRL, adrenaline, noradrenaline, lactate) will be collected perioperatively to compare stress in the two groups.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Signed Informed Consent * ASA II-III * Morbid obesity confirmed diagnosis and approval for surgical treatment * Laparoscopic sleeve gastrectomy (LSG) or Gastric By pass (R-Y By pass /SASI/SADI AND one anastomosis by pass ) * Preop respiratrory assessment conducted * Adequate organ and bone marrow function Exclusion Criteria: * Patients declining or withdrawing consent * Patients unsuitabe with regards to compliance to treatment, according to the researcher's assessment * Bradycardia, AV block, , postural hypotension * QTcF\>470msec * Known allergy or hypersensitiity to any of the medications administered * Stop-BANG score \>6 * Intraoperative administration of more than 8mg of prednisolone or equivalent * Patients who have received corticosteroids for durations \>3 weeks at any point in their lifetime * Participation in other clinical trial for experimental product administered post operatively * Diagnosis of depression
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What it tests

  • opioid free anesthesia
  • Opiod Free Anesthesia with TCI ELEVELD
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Where

1 site
General Hospital of Athens G. Gennimatas
Athens, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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