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tDCS for Reducing the Incidence of OEI After Cesarean Section

RecruitingNAAges 18 Years - 40 YearsAllAffiliated Hospital of Nantong University
NCT07569783 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cesarean section is the most common obstetric surgery worldwide. Epidural anesthesia has become the preferred anesthesia method for cesarean sections due to its definite analgesic effect and minimal impact on mother and baby. To ensure postoperative analgesia, intrathecal administration of morphine (the preferred opioid for obstetric intrathecal analgesia) is a routine clinical protocol, but morphine-induced postoperative pruritus is a common adverse reaction. A study targeting the cesarean section population confirmed that the incidence of pruritus after epidural morphine administration is as high as 40%-75%.Transcranial direct current stimulation (tDCS) can enhance the activity of GABAergic inhibitory interneurons in the spinal dorsal horn through the cortical-spinal descending pathway, reverse the inhibitory effect of morphine on them, and restore negative feedback regulation of itch-

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-40 years, gestational age 37-41 weeks, singleton full-term pregnancy; * Planned elective or emergency cesarean section, using epidural anesthesia (0.1\~0.2 mg/kg of morphine administered intrathecally during surgery); * American Society of Anesthesiologists (ASA) classification I-III; * Conscious and able to cooperate to complete scale assessments, serum sample collection, and postoperative follow-up; * Voluntarily participate in the study and sign the informed consent form. Exclusion Criteria: * Presence of contraindications for tDCS (such as skull defects, intracranial metal implants, history of epilepsy, coagulation disorders); * Allergy to opioids or a history of severe OEI; * Presence of skin diseases (such as eczema, urticaria), liver diseases (cholestasis), mental disorders, or cognitive impairments; * Coexisting pregnancy complications (preeclampsia, gestational diabetes, autoimmune diseases); * Use of medications within the past week that may affect itch assessment, such as antihistamines, 5-HT3 receptor antagonists, or anti-inflammatory drugs.
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What it tests

  • Transcranial direct current stimulation
  • Transcranial direct current stimulation (placebo stimulation)
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Where

1 site
Affiliated hospital of Nantong University
Nantong, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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