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Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT07569861 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which test patients prefer. The goal is to identify a simpler and more patient-friendly diagnostic approach.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 18 years 2. Hypotonic polyuria/polydipsia syndrome defined as polyuria \>40ml/kg body weight/24h and polydipsia \>3l/24h; and urine osmolality \<800mOsm/L or known AVP-D based on accepted criteria Exclusion Criteria: 1. Polyuria/polydipsia secondary to diabetes mellitus, hypercalcemia, or hypokalemia 2. Diagnosis of AVP-R (Copeptin \> 21.4 pmol/L) 3. Evidence of acute illness 4. Epilepsy requiring treatment 5. Uncontrolled arterial hypertension (blood pressure \>160/100mmHg at baseline 6. eGFR \< 60 ml/min/1,73 m2 7. Cardiac failure (NYHA III-IV) 8. Diagnosis of liver cirrhosis, Child-Pugh Class C 9. Uncorrected adrenal or thyroidal deficiency 10. Pregnancy or breastfeeding 11. Current or unresolved urinary obstruction 12. Enrollment in a clinical trial within the last 30 days 13. Patients refusing or unable to give written informed consent 14. Inability to follow study procedures
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What it tests

  • Mannitol
  • Hypertonic Saline
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Where

1 site
University Hospital Basel
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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