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Community-based Screening for Alzheimer's Disease

Recruitingn/aAges 60 Years - 80 YearsAllKuang XiaoJun
NCT07570719 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The goal of this prospective, multicenter, observational cohort study is to evaluate the screening performance of blood-based biomarkers for Alzheimer's disease (AD) in a real-world community screening setting, and to establish the population baseline levels and reference intervals of these biomarkers in Chinese older adults. The main questions it aims to answer is: What is the clinical screening value of blood biomarkers (phosphorylated tau 217 to amyloid ฮฒ 42 ratio \[pTau217/Aฮฒ42\] and glial fibrillary acidic protein \[GFAP\]) for AD among community-dwelling older adults? Eligible study participants will be randomly enrolled from community-dwelling older adults undergoing routine physical examinations and outpatient clinic attendees. All enrolled participants will undergo AD screening via blood biomarker testing. Participants with positive blood biomarker results (defined as abnormal

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Aged 60-80 years * Capable of normal communication and able to complete the questionnaire Exclusion Criteria: * Severe mental disorders * Severe visual, auditory, comprehension or mobility impairments * Current participation in other health intervention clinical studies * Severe renal insufficiency, heart failure, cerebrovascular disease, anemia, hyperthyroidism, hypothyroidism * Multiple cerebral infarctions, severe white matter hyperintensities, history of cerebral hemorrhage, current anticoagulant use, MRI abnormalities (cortical iron deposition, cerebral contusion) * Unable to comply with study procedures with no legal guardian
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What it tests

  • No study-specific intervention
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Where

4 sites
Fengcheng Community Health Service Center
Shanghai, China
Fengpu Community Health Service Center
Shanghai, China
Qingcun Community Health Service Center
Shanghai, China
Xidu Community Health Service Center
Shanghai, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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