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CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy

RecruitingNAAges 18 Years - 70 YearsFemaleHospital Provincial de Rosario
NCT07571473 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy. Surgical stress involves complex hemodynamic, endocrine, and inflammatory responses that may negatively impact postoperative recovery. Patients will be randomized to either anesthesia guided by conventional clinical and hemodynamic parameters or anesthesia additionally guided by CoreSys-derived indices of consciousness, nociception, and stress activity. The primary objective is to assess whether CoreSys-guided anesthesia attenuates stress biomarkers, including interleukin-6 (IL-6), cortisol and glycemia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female patients aged 18-70 years * Scheduled elective open abdominal hysterectomy in the morning * Written informed consent Exclusion Criteria: * Refusal to participate * Significant endocrine/metabolic disease * Pacemaker or major arrhythmias * Contraindication to epidural anesthesia
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What it tests

  • propofol
  • CoreSys Monitor
  • Remifentanil (Target-Controlled Infusion)
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Where

1 site
Hospital Provincial de Rosario
Rosario, Argentina
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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