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Assessment of cfDNA-STING Axis as a Potential Pathological Marker in Atopic Dermatitis

Recruitingn/aAges 18 Years - anyAllZhongda Hospital
NCT07573735 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Study Overview Atopic dermatitis (AD), commonly known as eczema, is a chronic inflammatory skin condition characterized by intense itching and skin barrier damage. While researchers know that the immune system is overactive in AD, it is difficult to measure the exact level of "damage" or "inflammation" happening deep within the skin using only a physical exam. The Purpose of This Study This study investigates a specific "danger signal" called circulating cell-free DNA (cfDNA). When skin cells are damaged or die due to inflammation, they release tiny fragments of DNA into the bloodstream. The investigators believe these fragments might act as a trigger for the immune system, worsening the disease. What the Study Involves Researchers will collect blood samples and small skin biopsies from patients with AD and healthy volunteers. The study aims to: Compare the levels of cfDNA in the bloo

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * Confirmed diagnosis of Atopic Dermatitis Exclusion Criteria: * Use of systemic immunosuppressants, systemic corticosteroids, or biological agents within 4 weeks prior to enrollment * Use of topical treatments within 2 weeks prior to enrollment
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What it tests

  • blood sampling
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Where

1 site
Zhongda Hospital, Southeast University
Nanjing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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