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Impact of Eradication Therapy on Helicobacter Pylori Infection With Chronic Obstructive Pulmonary Disease:

RecruitingPhase 1Ages 40 Years - anyAllZagazig University
NCT07574879 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Helicobacter pylori (HP) is a well-established pathogen responsible for chronic gastritis and peptic ulcer disease. Its presence has been implicated in the development of gastric malignancies such as adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. Chronic H. pylori infection is associated with systemic inflammatory responses and various extra gastric diseases, including cardiovascular, metabolic, and neurological disorders. Furthermore, H. pylori infection contributes to gastrointestinal dysbiosis by interacting with gastrointestinal microbiota, which may be involved in gastric carcinogenesis and other systemic disorders. Growing evidence highlights the role of dysbiosis in chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Emerging epidemiological evidence suggests a potential association between H. pylori infection and respirat

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged ≥40 years. * Diagnosed with COPD confirmed by spirometry (post-bronchodilator FEV1/FVC \< 0.70) and H. pylori positive. * Willing to participate and provide consent for testing and follow-up. Exclusion Criteria: * patients with asthma, known peptic ulcers, acute exacerbation of COPD * patients who took antibiotics and PPIs within the last month, * Patients who took histamine-2-receptor antagonists within the last week or antacid within the last 24 hours a * those having H. pylori eradication treatment within the last 6 months
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What it tests

  • Eradication of Helcobacter Pylori
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Where

1 site
Zagazig University outpatients clinics
Zagazig, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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