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Calcium Replacement Therapy in Postoperative Hypoparathyroidism

RecruitingNAAges 18 Years - anyAllTartu University Hospital
NCT07577570 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate whether a lower-dose calcium replacement therapy is non-inferior to a higher-dose regimen in preventing symptomatic hypoparathyroidism in patients following thyroidectomy. The hypothesis is: • lower-dose calcium replacement therapy is non-inferior to higher-dose therapy in preventing symptomatic hypoparathyroidism during the first two postoperative weeks Researchers will compare patients receiving a lower-dose calcium replacement regimen with those receiving a higher-dose regimen to assess whether the lower dose is not associated with a higher incidence of symptomatic hypoparathyroidism. Patients who develop post-thyroidectomy hypoparathyroidism are divided into groups for calcium replacement therapy. If they are asymptomatic, they will be scheduled for a follow-up visit at two weeks after surgery. During the follow-up visit, calcium meta

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📋 Eligibility rules (as published)
Inclusion Criteria: * patients over the age of 18 undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, "near-total" thyroidectomy, subtotal thyroidectomy, and "completed" thyroidectomy) * Based on the first post-operative day analysis, PTH levels are below the normal range (in our hospitals 1.8-7.8 pmol/l), but not so low (below 1.06 pmol/L) as to require calcium replacement therapy with calcitriol (rocaltrol) Exclusion Criteria: * previously diagnosed osteoporosis; the patient is already taking calcium and vitamin D supplements prior to thyroid surgery * renal insufficiency (eGFR \< 30) * patients with concomitant hyperparathyroidism undergoing simultaneous thyroidectomy and parathyroidectomy for a parathyroid adenoma
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What it tests

  • Calcium carbonate 1250 mg (500 mg elemental calcium) twice a day
  • Calcium carbonate 1250 mg (500 mg elemental calcium) 4 times a day
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Where

2 sites
East Tallinn Central Hospital
Tallinn, Estonia
Tartu University Hospital
Tartu, Estonia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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