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Infusion of Furosemide to Improve Diuretic Efficiency in Acute Heart Failure

RecruitingPhase 4Ages 18 Years - anyAllUniversity of Aarhus
NCT07577596 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute heart failure is a condition where the heart suddenly cannot pump blood well enough for the body's needs. Many people admitted to the hospital with acute heart failure have too much fluid in the body. This can cause shortness of breath, swelling, and the need for treatment with water-removing medicine. Furosemide is a commonly used water-removing medicine that is given into a vein to treat fluid overload. It can be given in different ways. One way is as a continuous infusion, where the medicine is given slowly over time through a pump. Another way is as repeated injections given several times a day. It is not known whether one of these ways is better than the other for removing excess fluid in people with acute heart failure. The purpose of this study is to compare two ways of giving furosemide into a vein: Continuous infusion started with an initial extra dose, and bolus injecti

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📋 Eligibility rules (as published)
Inclusion Criteria: * Clinical diagnosis of acute heart failure with volume overload * At least 1 sign of volume overload * Anticipated intravenous furosemide treatment for at least 3 days * Age 18 years or older Exclusion Criteria: * Shock * Patient requiring treatment with inotropes or vasopressors * Current or planned use of renal replacement therapy or ultrafiltration * Patient with a renal transplant * Patients who are pregnant or breastfeeding * Severe hypokalaemia, defined as potassium less than 2.5 mmol/L, or severe hyponatremia, defined as sodium less than 125 mmol/L * Allergy to furosemide and its components
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What it tests

  • Intravenous furosemide continuous infusion
  • Intravenous furosemide bolus injections
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Where

1 site
Department of Medicine, Randers Regional Hospital
Randers, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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