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Spatial Scene Recognition Memory in Epilepsy Surgery

RecruitingNAAges 18 Years - 55 YearsAllUniversity of California, Davis
NCT07580183 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial/scene memory, recollective experience, and familiarity processing. Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures. In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions. In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition. In Aim I

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * For Aims I and III: Diagnosis of focal epilepsy or temporal lobe lesion; patients undergoing evaluation for or having undergone epilepsy surgery * For Aim II: Healthy adult participants * Full-Scale IQ ≥ 70 * English proficiency sufficient to understand and complete the task * For Aim I: Enrolled in or eligible for Emory University epilepsy surgery research registry * For Aim III: Undergoing clinically indicated stereoelectroencephalography (SEEG) at UC Davis Medical Center * Able to provide informed consent (or for Aim I retrospective component, prior consent in Emory registry) Exclusion Criteria: * Full-Scale IQ \< 70 * Inability to provide informed consent * For Aim III: Age \> 55 years * For Aim II: History of neurological or psychiatric disorder (as applicable per study protocol)
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What it tests

  • Virtual Tour Recognition Memory Task
  • Intracranial EEG Recording with Research Electrodes (Aim III only)
  • MRI Neuroimaging and Neuropsychological Assessment (Aim I)
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Where

2 sites
UC Davis Medical Center
Sacramento, United States
Emory University Hospital
Atlanta, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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