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Spasticity in SCI Following Acute Intermittent Hypoxia

RecruitingNAAges 18 Years - anyAllZev Rymer
NCT07583498 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>= 18 * Non-progressive spinal Cord injury at least 6 months prior * Level of injury between C1-C8 * ISNCSCI ASIA classification C or D * Measurable Spasticity Exclusion Criteria: * Pre-existing hypoxic pulmonary disease * Positive Covid-Pneumonia diagnosis within 1 year of visit * Uncontrolled hypertension \>140/90 mmHg * Individuals who are currently pregnant/nursing or planning on becoming pregnant * Individuals with a tracheostomy or who utilize mechanical ventilation * A botulinum toxin injection to upper extremity musculature within the past 3 months * Currently taking Baclofen * Congestive Heart Failure * Cardiac arrhythmias * Uncontrolled diabetes mellitus * Chronic obstructive pulmonary disease * Emphysema * Severe Asthma * Previous myocardial infarction * Carotid/intracerebral artery stenosis * Orthopedic injuries or surgeries that impact the ability to use the upper extremity * History of Epilepsy
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What it tests

  • Acute Intermittent Hypoxia (AIH)
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Where

1 site
Shirley Ryan AbilityLab
Chicago, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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