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PERCEPTION - Super-Early Neuroprognostication in eCPR Patients

Recruitingn/aAges 18 Years - anyAllMedical University of Vienna
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In plain words

What the trial is, and whether it could suit you

Background Extracorporeal cardiopulmonary resuscitation (eCPR) is a rescue therapy for a selected group of patients. Extracorporeal membrane oxygenation (ECMO) is initiated to bypass the cardiac system and bridge time to definitive treatment of the cardiac arrest (CA) origin. eCPR treatment is very time-critical and, if indicated, should be initiated as early as possible. Patient selection for this highly specific treatment is challenging and relies on numerous factors. In the following phase of intensive care treatment, neuroprognostication is performed. However, following current guidelines, this is only recommended 72hours after CA. Once ECMO is initiated, a complex intensive care treatment is expected, without a guarantee for full neurological recovery. There is a recognized clinical need for more precise selection criteria, alongside predictive values, to enable earlier, reliable ne

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * All patients โ‰ฅ 18 years evaluated for eCPR treatment at the Department of Emergency Medicine Exclusion Criteria: * Return of spontaneous circulation before ECMO initiation. * Anatomical infeasibility for measurement, including but not limited to: * Severe facial trauma or deformity preventing the placement of the automated pupillometry device. * Scalp injuries, dressings, or conditions that interfere with the correct positioning of near-infrared spectroscopy (NIRS) sensors. * Pre-existing ocular conditions that preclude reliable pupillometry (e.g., enucleation, opaque cornea, or severe anisocoria unrelated to neurological status).
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What it tests

  • Automated Pupillometry
  • continuous near-infrared spectroscopy (cNIRS)
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Where

1 site
Department of Emergency Medicine, Medical University of Vienna
Vienna, Austria
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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