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Comparative Evaluation of Nicotine Analogs

RecruitingPhase 1Ages 21 Years - anyAllOhio State University Comprehensive Cancer Center
NCT07585006 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This phase I trial compares electronic cigarette (EC) user preferences and smoking behaviors of nicotine analogs to nicotine to improve the understanding of nicotine analog addictiveness. Over the last ten years, EC use has become a major concern due to its increased use among adolescents and young adults. Though progress has been made in regulating nicotine containing products, some companies have shifted toward producing products containing nicotine analogs. ECs are battery-powered electronic devices designed to atomize a nicotine (the poisonous chemical found in tobacco)-containing liquid solution for inhalation in a manner that simulates smoking a tobacco cigarette. When nicotine enters the body, it causes an increased heart rate and use of oxygen by the heart, and a sense of well-being and relaxation. Nicotine analogs are compounds that are similar to nicotine in their chemical stru

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 21 years or older * Current adult EC user for at least the past 3 months (confirmed by cotinine testing strip) * Willing and able to provide informed consent * Willing to abstain from using any nicotine, tobacco, or marijuana products for 12 or more hours prior to the three lab visits * Able to read, write, and speak English Exclusion Criteria: * Currently attempting to quit nicotine or tobacco products * Use of other tobacco or nicotine products \> 10 days in the past month * Have had a recent cardiac event or distress (defined as occurring within the previous 3 months) * Have had a recent serious lung disease or infection (e.g., tuberculosis, cystic fibrosis, asthma, or lung cancer) (defined as occurring in the previous 30 days) * Currently pregnant, planning to become pregnant, or breastfeeding (verified with urine pregnancy test)
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What it tests

  • Biospecimen Collection
  • Nicotine
  • 6-Methyl Nicotine
  • nicotinamide
  • Puffing Topography Research
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Where

1 site
Ohio State University Comprehensive Cancer Center
Columbus, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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