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Paracetamol and Cefazolin Pharmacokinetics in Normal Weight and Overweight Children

Recruitingn/aAges 2 Years - 15 YearsAllUniversity Hospital, Ghent
NCT07585487 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pharmacokinetic evaluations will be conducted to characterize the cefazolin plasma concentration-time profile, cefazolin penetration into subcutaneous adipose tissue, and paracetamol metabolization as assessed through blood sampling. The study population consists of children aged 2 to 15 years with either normal weight or overweight. All participants are admitted for a minor elective surgical procedure and will receive paracetamol and/or cefazolin as part of standard perioperative care. During the procedure, multiple blood and tissue-fluid samples will be collected to quantify paracetamol and cefazolin concentrations in the bloodstream, as well as cefazolin concentrations in subcutaneous adipose tissue. The study aims to characterize drug concentration-time profiles in blood (paracetamol), plasma (cefazolin), and adipose tissue (cefazolin), and to compare these pharmacokinetic parameter

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient admitted to the operating room for minor elective surgery * Patients undergoing general anesthesia for minor elective surgery * Patient age: children from 2 years to 15 years * Patients receiving cefazolin or paracetamol according to the standard procedure * Intra-arterial (preferred) or intravenous access available for blood sampling * BMI Exclusion Criteria: * Personal or family history of excessive bleeding * Pre-existing coagulopathy and/or thrombocytopenia * No catheter available for blood sampling * Absence of parental consent * Known allergy to one of the components of the study * Pregnancy
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What it tests

  • Cefazolin
  • Paracetamol (drug)
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Where

1 site
Ghent University Hospital, Ghent
Ghent, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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