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Molecular Profiling for Risk Stratification in Appendiceal Cancer

Recruitingn/aAges 18 Years - anyAllCity of Hope Medical Center
NCT07587268 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient cohort. The study includes DNA methylation profiling and m6A epitranscriptomic profiling to define molecular subtypes, evaluate associations with clinicopathologic features, and develop molecular risk scores for prognostic stratification. The primary goal is to determine whether DNA methylation- and m6A-based molecular features can complement conventional histopathologic grading and improve risk stratification.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with histologically confirmed appendiceal adenocarcinoma or appendiceal cancer. * Availability of archived tumor tissue suitable for molecular profiling. * Availability of tissue for DNA methylation profiling, m6A epitranscriptomic profiling, or both. * Availability of relevant clinicopathologic data. * Availability of survival or follow-up information when applicable. * Age 18 years or older at diagnosis or tissue collection. Exclusion Criteria: * Insufficient tissue quantity or quality for molecular profiling. * Inadequate DNA or RNA quality for sequencing or molecular assay preparation. * Missing essential clinicopathologic information required for analysis. * Non-appendiceal primary tumor or metastatic tumor to the appendix from another primary site. * Patients who do not meet institutional review board or consent requirements, if applicable.
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What it tests

  • DNA Methylation Profiling
  • m6A Epitranscriptomic Profiling
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Where

1 site
City of Hope Medical Center
Durate, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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