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Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Cardiac Surgery Patients

Recruitingn/aAges 18 Years - 80 YearsAllYan Fuxia
NCT07588178 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is titled "Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Adult Cardiac Surgery". It aims to clarify the perioperative metabolic changes caused by preoperative sleep disorders in adult cardiac surgery patients, providing ideas for exploring the mechanism by which sleep disorders affect adverse outcomes after cardiac surgery. The study will be conducted at Fuwai Hospital, Chinese Academy of Medical Sciences. By collecting perioperative blood and fecal samples from adult cardiac surgery patients with and without preoperative sleep disorders, and simultaneously recording postoperative clinical outcome indicators (such as the incidence of delirium within 7 days after surgery, cognitive function scores, mechanical ventilation time, ICU stay time, hospital stay time, and severe cardiovascular adverse events),

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥ 18 years 2. Scheduled for elective cardiac surgery Exclusion Criteria: 1. Has a history of neurosurgery, or has suffered from neurological diseases such as cerebral hemorrhage, cerebral infarction, delirium, dementia, etc. 2. Has a history of mental disorders. 3. Heavy alcohol consumption. 4. American Society of Anesthesiologists (ASA) classification level IV or above. 5. Complicated with severe liver dysfunction (Child-Pugh C grade) or renal dysfunction (chronic kidney disease stage 3-4). 6. Unable to communicate due to hearing or language problems, or refuses to sign the informed consent form.
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What it tests

  • This is a observational study and there is no intervention.
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Where

1 site
Fuwai Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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