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Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease

RecruitingNAAges 18 Years - anyAllMaria Cecilia Hospital
NCT07588295 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages. This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with chronic coronary artery disease; * Patients with no-ST elevation acute coronary syndrome; * Patients with chronic claudication (Rutherford II-III) * Patients with critical limb ischemia (Rutherford IV-V). Exclusion Criteria: * Severe renal dysfunction * Severe valve disease * Advanced heart failure * Advanced liver disease * Chronic inflammatory or autoimmune disease * Use of antinflammatory drugs * Acute infection * Recent surgical procedures
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What it tests

  • Optical Coherence Tomography assessment
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Where

1 site
Maria Cecilia Hospital
Cotignola, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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