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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

RecruitingPhase 2Ages 18 Years - 75 YearsAllEli Lilly and Company
NCT07589608 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

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📋 Eligibility rules (as published)
Inclusion Criteria: * See Master Protocol CWMM (NCT06143956) for inclusion criteria Exclusion Criteria: In addition to exclusion criteria in Master Protocol CWMM (NCT06143956): * Have type 1 diabetes or type 2 diabetes * Have an ongoing history of bradyarrhythmia and/or sinus bradycardia * Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm) * Have a history of acute or chronic pancreatitis * All concomitant medications should be at a stable dose for at least 3 months prior to screening
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What it tests

  • Macupatide
  • Eloralintide
  • Placebo
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Where

40 sites
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa
Chandler, United States
Headlands Research - Scottsdale
Scottsdale, United States
The Institute for Liver Health II dba Arizona Liver Health-Tucson
Tucson, United States
NorCal Medical Research, Inc
Greenbrae, United States
Velocity Clinical Research, Huntington Park
Huntington Park, United States
Peninsula Research Associates
Rolling Hills Estates, United States
Diablo Clinical Research, Inc.
Walnut Creek, United States
Stamford Therapeutics Consortium
Stamford, United States

…and 32 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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