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BFR Training and Knee Osteoarthritis

RecruitingNAAges 40 Years - 70 YearsAllUniversity of Hail
NCT07590323 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Knee osteoarthritis (KOA) is a chronic, progressive degenerative joint disease characterized by cartilage and bone degeneration, synovial inflammation, and structural changes. Clinically, it presents with pain, morning stiffness, swelling, crepitus, and limited range of motion, leading to functional impairment, gait abnormalities, and reduced quality of life. Globally, KOA affects \~302 million people. In Saudi Arabia, prevalence rises from 30.8% (ages 46-55) to \>60% (ages 66-75), with higher rates in older, female, and obese individuals. Key risk factors include aging, female sex, obesity, prior knee injury, and genetics. The condition imposes significant health burdens and socioeconomic costs. The International Classification of Functioning, Disability, and Health (ICF) identifies KOA as a major cause of physical disability. Pain, restricted motion, and muscle weakness drive quality-

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female Age ≥ 40years. * Clinical and radiographic diagnosis of unilateral knee osteoarthritis KOA (Kellgren-Lawrence grade 2, or 3). * Willing to attend 3 supervised sessions/week for 8 weeks. * Able to provide informed consent. Exclusion Criteria: * Peripheral vascular disease, active cancer, lower limb infection, open wound * history of intra-articular injections within the last 3 months * medical condition that may affect their ability to perform exercise (uncontrolled cardiovascular, or neurological disorders) * cognitive and psychiatric disorders
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What it tests

  • Standard Treatment
  • Pain neuroscience education
  • Blood flow restriction training
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Where

1 site
University of Hail
Ha'il, Saudi Arabia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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