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Effects of the Menstrual Cycle and Oral Contraceptive Use on Health and Performance in Athletes

Recruitingn/aAges 18 Years - 30 YearsFemaleFaculdade de Motricidade Humana
NCT07591818 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A review of the sports medicine literature reveals a clear underrepresentation of female athletes in research. In the current era of precision medicine, increasing attention has been directed toward the regulatory roles of estrogen and progesterone in athletic performance and health optimization. Regular fluctuations in estrogen and progesterone across menstrual cycle phases (i.e., early follicular, late follicular, and mid-luteal phases) may influence strength performance, hydration status, body composition, and energy balance. However, few studies have examined these outcomes using hormonal confirmation of menstrual cycle phases. Monophasic oral contraceptive use also represents a highly relevant hormonal condition among female athletes, as exogenous hormones suppress endogenous ovarian fluctuations and create distinct hormonal profiles across active pill-consumption and withdrawal pha

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📋 Eligibility rules (as published)
Inclusion Criteria: * Cisgender female individuals (biologically female, not undergoing gender-transition therapy) * Age between 18 and 30 years; * Classified as at least Tier 2 athletes; * Minimum of 1 year of federated sports participation; * Menarche occurred at least 3 years prior to enrollment; Additional inclusion criteria for the natural menstrual cycle group: * Menstrual cycle length between 21 and 35 days with at least nine consecutive cycles in the previous year; * Confirmed ovulatory cycle (luteinizing hormone surge and progesterone \>16 nmol/L); Additional inclusion criteria for the oral contraceptive group: * Use of combined monophasic oral contraceptives with a 21-day regimen; * Use of the same oral contraceptive for at least 3 months prior to enrollment; Exclusion Criteria: * Pregnancy or child birth within the previous 12 months; * Active smoking; * Diagnosis of metabolic, cardiovascular, or respiratory disease: * Use of continuous or extended-cycle oral contraceptives.
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What it tests

  • Not listed
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Where

1 site
Faculdade de Motricidade Humana
Cruz Quebrada, Portugal
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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