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A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3Ages 18 Years - 74 YearsAllDefinium Therapeutics US, Inc.
NCT07592689 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Diagnosis of MDD per DSM-5 2. Male or female aged 18 to 74 3. Currently experiencing a major depressive episode (MDE) of ≥8 weeks and ≤24 months duration 4. MADRS Total Score ≥26 5. CGI-S Score ≥4 Exclusion Criteria: 1. Certain psychiatric disorders (other than major depressive disorder) 2. First degree relative with or lifetime history of a psychotic disorder or bipolar disorder 3. Current diagnosis of alcohol or substance use disorder (excluding nicotine and caffeine 4. Any clinically significant unstable illness
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What it tests

  • Placebo
  • DT120
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Where

30 sites
Preferred Research Partners, Inc.
Little Rock, United States
ATP Clinical Research Orange County
Orange, United States
Kadima Neuropsychiatry Institute
San Diego, United States
UCSF Department of Neurology
San Francisco, United States
Psychedelic Science Institute
Santa Monica, United States
Mountain View Clinical Research, Inc
Denver, United States
Clinical Neuroscience Solutions, LLC (Jacksonville)
Jacksonville, United States
K2 Medical Research (Maitland)
Maitland, United States

…and 22 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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