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Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE

Recruitingn/aAges 18 Years - anyAllSt. Jude Children's Research Hospital
NCT07594392 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Childhood cancer survivors are at increased risk for premature atherosclerotic cardiovascular disease (ASCVD) due to cancer treatment-related exposures, including radiation therapy and platinum-based chemotherapy. Current ASCVD risk assessment tools may underestimate cardiovascular risk in younger survivors. This observational study performs detailed cardiovascular phenotyping using imaging, blood-based biomarkers, and vascular function testing among adult survivors enrolled in the St. Jude Lifetime Cohort (SJLIFE), with comparison to community controls, to better characterize subclinical ASCVD risk and inform survivor-specific prevention strategies. Primary Objective: Perform deeper phenotyping of SJLIFE participants at treatment-related risk of atherosclerotic cardiovascular disease \[ASCVD\] to facilitate early detection of pathophysiological targets appropriate for remediation. Se

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📋 Eligibility rules (as published)
Inclusion Criteria: \- SJLIFE Survivor or Control * Age ≥18 years * Enrolled in the St. Jude Lifetime Cohort (SJLIFE) * Participant or legal guardian/representative is able and willing to give informed consent. SJLIFE Survivor only * Participant has been treated with at least one of the following cancer therapies: platinum chemotherapy, neck radiation exposure of at least 1000 centigray (cGy), or chest radiation exposure of at least 1000 cGy (with potential exposure to the heart). Exclusion Criteria: SJLIFE Survivor or Control * Previous stroke or intervention for severe carotid arterial disease including carotid endarterectomy or carotid angioplasty and stent placement. * Previous myocardial infarction or intervention for severe cardiovascular disease including Coronary Artery Bypass Graft (CABG), coronary stent placement or coronary angioplasty. * History of aortic valve replacement * Inability or unwillingness of research participant or legal guardian/representative to give written informed consent. Control Only * First degree relative of SJLIFE Survivor * History of cancer
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What it tests

  • Coronary Artery Calcium Scan
  • Carotid Artery Ultrasound
  • Lipoprotein(a) Measurement
  • Vascular Function Testing
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Where

1 site
St. Jude Children's Research Hospital
Memphis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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