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The Effect of Low or High Dietary Fiber Diet on Volatile Organic Compounds in Exhaled Breath of Healthy Individuals

RecruitingNAAges 18 Years - 65 YearsAllÖrebro University, Sweden
NCT07594600 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this crossover intervention study is to evaluate the volatile organic compounds (VOCs) present in participants at baseline and how these levels change after consuming either a low- or high-dietary fiber diet for three days. This study will involve adults, 18-65 years old, without any gastrointestinal diseases. The primary objectives are to characterize baseline VOC profiles, assess changes in these profiles after a short-term dietary fiber intervention, determine if specific VOC patterns correlate with dietary fiber intake, and identify the time points at which VOC levels peak. This information will help establish the optimal timing for breath sampling and potentially provide insight into how VOC patterns relate to dietary fiber consumption and degradation. The expected outcome is that a high-dietary fiber diet will produce a VOC profile enriched in metabolites associated wi

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Signed informed consent obtained prior to any study-related procedures. 2. Willingness to refrain from regular consumption of prebiotic or probiotic products, as well as medications known to affect gastrointestinal function, for at least four weeks prior to the study visits. Exclusion Criteria: 1. History of complicated gastrointestinal surgery. 2. Presence of a gastrointestinal diagnosis or any condition that, in the opinion of the principal investigator, may influence the study outcomes. 3. Current diagnosis of a psychiatric disorder. 4. Systemic use of antibiotics or steroid medications within the past 3 months. 5. Frequent use of NSAIDs (non-steroidal anti-inflammatory drugs) within the 2 months preceding the study visit. 6. Regular consumption of prebiotic or probiotic products within the past 4 weeks. 7. Alcohol or substance abuse. 8. Current smoking or use of nicotine pouches. 9. Frequent use of laxatives, antidiarrheal agents, or anticholinergic medications within the 12 weeks preceding the study visit. 10. Pregnancy or breastfeeding. 11. Respiratory disease or infection.
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What it tests

  • Low, High Fiber Diet
  • High, Low Fiber Diet
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Where

1 site
Örebro University
Örebro, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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