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Effect of High Versus Standard Protein Intake in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

RecruitingNAAges 18 Years - anyAllChulalongkorn University
NCT07596043 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

During critical illness, patients experience a hypercatabolic state. This hypercatabolic state causes muscle wasting in patients, resulting in intensive care unit acquired weakness (ICU-AW). ICU-AW is associated with prolonged mechanical ventilation (MV) weaning, extubating failure and extended length of stay. Previously recognized risk factors for ICU-AW include shock, sepsis, multiple organ failure, hyperglycemia, and prolonged exposure to corticosteroids, sedatives, or paralytic agents. Critical illness is complicated by the development of acute kidney injury (AKI). AKI causes muscle wasting by increasing protein degradation and decreasing protein synthesis. Furthermore, patients with severe AKI often require renal replacement therapy (RRT), which contributes to additional protein loss. Studies have estimated that amino acid losses associated with RRT may range from 5 to 19 g/d, with

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult (≥18 years old) * AKI receiving CRRT within 7 days after ICU admission * Achieve and tolerate calories 70% of target daily caloric requirement (20 kcal /kg/d) within 7 days after ICU admission by enteral feeding * Participant or their surrogates is willing and able to give informed consent for participation in the study Exclusion Criteria: * Moribund or withholding of treatment * Kidney transplant recipient * Previously diagnosed end-stage kidney disease (ESKD) currently on kidney replacement therapy * Pregnancy or breastfeeding * Hepatic encephalopathy (West Haven grade 3-4) * Burn patients * Patients whom the responsible clinician felt that the patient either needed low or high protein * Severe complications of diabetes such as ketoacidosis, hyperosmolar coma * Had pre-existing neuromuscular disorders * Previously leg amputations
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What it tests

  • High protein group
  • Standard protein group
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Where

1 site
King chula memorial hospital
Bangkok, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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