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Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers

RecruitingNAAges 18 Years - 65 YearsAllMarmara University
NCT07597213 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to evaluate whether hyaluronic acid (HA) improves periodontal healing in people with periodontal disease who smoke. Moreover, the effects of HA on biomolecules and bacteria levels will be assessed during the follow up period. The main questions it will answer are: Will periodontal sites treated with HA gel after non-surgical periodontal treatment (NSPT) lead to better outcomes in clinical parameters compared to the sites treated with NSPT only in smokers? Will adjunctive use of HA gel reduce oxidative stress markers and bacteria levels during follow-up? Researchers will compare periodontal sites receiving NSPT with adjunctive HA gel application to sites receiving NSPT alone to determine whether HA provides additional clinical, biochemical and microbiological benefits. Participants will: * first receive full-mouth NSPT then, randomization will be p

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Individuals who sign the informed consent form 2. Participants who are systemically healthy 3. Participants who smoke (for \>5 years and ≥10 cigarettes per day) 4. Participants diagnosed with Stage III or Stage IV periodontitis 5. Participants with at least 20 natural teeth present in the mouth (excluding third molars) 6. Participants with two non-adjacent interproximal sites in each quadrant of either jaw, presenting probing depth (PD) and clinical attachment level (CAL) ≥6 mm, and with no caries, restorations, or furcation involvement Exclusion Criteria: 1. Individuals who do not sign the informed consent form 2. Individuals having any systemic disease 3. Participants who have used antibiotics within the last 3 months 4. Participants who have received any periodontal treatment within 6 months prior to the study 5. Participants who are pregnant or lactating
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What it tests

  • Scaling and Root Planing
  • Hyaluronic Acid (HYADENT BG)
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Where

1 site
Department of Periodontology, Faculty of Dentistry, Marmara University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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