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EVERiST: Impact of Image Detected Accessory Pudendal Artery on Erection Recovery After Nerve Sparing Prostatectomy

Recruitingn/aAges 18 Years - 79 YearsMaleUniversity College, London
NCT07597798 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prostate cancer is the most common cancer amongst men in the United Kingdom, and two common curative treatments are surgery to remove the prostate (radical prostatectomy) or radiotherapy. Both treatments can affect quality of life, mainly because of problems with erections and urinary leakage. Many men feel disappointed or regret their treatment choice because of changes in their sexual function. Surgeons often use a 'nerve-sparing' technique to reduce the risk of erectile dysfunction (ED), but many men still experience erection problems afterwards. A way to improve erectile function recovery after surgery further would be to identify accessory (additional) arteries to the penis. Up to one in three men have an extra artery called the accessory pudendal artery (APA). Preserving this artery during surgery may improve recovery of erections by protecting blood flow and reducing the risk or s

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men diagnosed with cT2-T3a N0 M0 PCa aged between 18 and 79 from all ethnic backgrounds. * Patients who underwent a prostate mpMRI before prostate biopsy. * Medically fit to undergo RARP. * Diagnostic quality prostate biopsies concordant with a diagnostic quality prostate mpMRI adequate to provide a surgical plan. * Scheduled for RARP with a recommendation of NVB spare based on multidisciplinary meetings informed by mpMRI, biopsy result and clinical factors. * Sexually active men with no to mild ED at baseline based on IIEF-EFD (\>=24) questionnaire. * Preference to preserve erectile function for sexual intercourse. * Ability to read English sufficiently to understand PIS and able to give informed consent. Exclusion Criteria: * Established moderate/ severe ED (IIEF-EFD \<24) * Patients who received neo-adjuvant androgen deprivation therapy. * Patients with previous surgery for benign prostatic enlargement * Patients who received previous treatment for prostate cancer: External beam radiotherapy, brachytherapy, focal therapy, chemotherapy. * Previous pelvic or penile fracture * Previous surgery for ED * Poor quality prostate mpMRI or biparametric MRI (no contrast) * Established vascular disease (ischaemic heart disease, cerebrovascular disease, peripheral vascular disease)
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What it tests

  • Robotic Radical Prostatectomy
  • Penile doppler ultrasound
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Where

1 site
University College London Hospitals NHS foundation trust
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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