AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Study of Feasibility for Surgical Patients Undergoing Heart Surgery With the Mammary Arteries: Reviewing Infection, Occlusion Rates and Pain Assessments.

RecruitingNAAges 18 Years - anyAllOttawa Heart Institute Research Corporation
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

The Pilot study for the COMFORT Trial is a single centre trial to determine the feasibility of the full COMFORT Trial. The main COMFORT Trial will be a multi-centre trial to investigate the coronary artery bypass grafting outcomes when harvesting the Left Internal Mammary Artery (LIMA) using a skeletonized approach (artery is isolated without the surrounding veins, fascia and nerves) compared to harvesting the LIMA using a non-skeletonized approach (artery is isolated with the surrounding veins, fascia and nerves). Harvesting the LIMA with the non-skeletonized approach is the standard technique. Participants will complete a Coronary Artery Tomography scan at 1 year to determine if the LIMA graft remains open. Follow up of the participants will continue until 2 years post surgery.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or older * Undergoing isolated CABG surgery with median sternotomy and a planned LIMA-LAD graft. * Provision of written informed consent. Exclusion Criteria: * Non-sternotomy surgical approach (e.g., minimally invasive, thoracotomy) * Emergency surgery (defined as surgery required within 24 hours or presentation * History of prior ternotomy * Currently receiving systemic antibiotics or with an active bacterial infection at the time of surgery * History of chronic sternal pain prior to the index surgery. * Known left subclavian artery stenosis (\>50%) * Previous radiation therapy to the chest * Known allergy or contraindication to iodinated contrast media that cannot be managed with premedication. * Estimated glomerular filtration rate (eGFR) \<30 ml/min/1.73m2 at baseline (relative contraindications to CTA contrast). The eGFR will be determined by each participating institution according to their standard practice.
๐Ÿ’Š

What it tests

  • Skeletonized vs non-skeletonized harvesting of the left internal mammary artery
๐Ÿ“

Where

1 site
University of Ottawa Heart Institute
Ottawa, Canada
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy