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Surfactant Protein D Levels in GCF Before and After MINST in Periodontitis

RecruitingNAAges 18 Years - anyAllCairo University
NCT07599657 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will evaluate changes in Surfactant Protein D (SP-D) levels in gingival crevicular fluid (GCF) of patients with periodontitis before and after minimally invasive non-surgical periodontal therapy (MINST). Participants diagnosed with stage II or III periodontitis will receive minimally invasive non-surgical periodontal treatment. GCF samples will be collected at baseline and 6 months after treatment, and SP-D levels will be measured using enzyme-linked immunosorbent assay (ELISA). The study will also assess clinical periodontal outcomes, including full-mouth plaque score, full-mouth bleeding score, probing pocket depth, clinical attachment level, gingival recession, and patient satisfaction. Each participant will serve as their own control by comparing baseline values with 6-month post-treatment values.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female participants aged 18 years or older. * Diagnosis of periodontitis, classified as stage II or stage III according to the 2018 classification system. * Presence of at least one tooth with probing pocket depth (PPD) of 5 mm or more, clinical attachment loss (CAL), and radiographic evidence of bone loss. * Presence of at least one intrabony defect with a radiographic intrabony component measuring 3 mm or more. Exclusion Criteria: * Current smokers or individuals with a history of smoking within the past year. * Pregnant or lactating women. * Use of systemic antibiotics or anti-inflammatory medications within the last 3 months. * Known allergy to any materials or agents used during periodontal therapy.
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What it tests

  • Minimally Invasive Non-Surgical Periodontal Therapy
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Where

1 site
Faculty of Dentistry, Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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