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Evaluation of Tissue and Circulating microRNA Profiles in Patients With Hepatocellular Carcinoma Subjected to Thermal Ablation

Recruitingn/aAges 18 Years - 64 YearsAllIRCCS Azienda Ospedaliero-Universitaria di Bologna
NCT07601464 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main objectives of this research project concern the identification of microRNAs circulating and of serum metabolites predictive of treatment response in patients with early stage hepatocellular carcinoma undergoing locoregional treatment with thermoablation. In addition, the molecular mechanisms involved in reprogramming will be identified metabolic via bioinformatics analysis and pretreatment liver biopsy analysis and analysis of screening on patient-derived primary lines for personalized therapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 * Diagnosis of hepatocarcinoma confirmed by radiology (LIRADS criteria/triphasic diagnostics) or by biopsy. * Indication for thermoablation treatment (for radiofrequency) based on the judgment of the hepatologist/surgeon. * Informed consent signed by the patient. Exclusion Criteria: * Presence of metastatic liver lesions of other origins. * History of liver transplant. * Severe, uncorrectable coagulopathy, contraindicating liver biopsy (where necessary) or ablative procedure. * Patient refusal to participate in the study or inability to obtain informed consent. * Pregnant women.
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What it tests

  • Not listed
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Where

1 site
IRCCS Policlinico di Sant'Orsola
Bologna, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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