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Pulsed Field Ablation Outcomes With Efficacy and Randomization in Atrial Fibrillation (POWER-AF)

RecruitingNAAges 18 Years - anyAllChina National Center for Cardiovascular Diseases
NCT07601763 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. As of 2019, there were approximately 59.7 million patients with AF worldwide, including atrial flutter (AF). Atrial fibrillation can significantly increase the risks of stroke, thromboembolism and heart failure in patients, seriously affecting their quality of life. Catheter ablation is the main means for rhythm control in patients with atrial fibrillation. A large number of clinical studies have confirmed the effectiveness and safety of catheter ablation for atrial fibrillation. It is significantly superior to drug treatment in maintaining sinus rhythm and can significantly improve symptoms and quality of life. Pulsed electric field ablation (PFA) is a novel ablation method that utilizes pulsed electric fields as energy. It uses multiple short-duration and high-voltage electrical pulses to release abl

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Atrial fibrillation patients who will accept catheter ablation. 2. Age ≥ 18. 3. Be capable of understanding and signing the informed consent form. Exclusion Criteria: 1. Have contraindications for catheter ablation (such as atrial thrombosis, decompensated heart failure, etc.) 2. Have accepted catheter ablation before. 3. Myocardial infarction, or any cardiac interventional/surgery has been performed within 3 months. 4. Had a stroke or transient ischemic attack within 6 months. 5. Allergy to iodine contrast agents. 6. Participate in clinical trials related to other drugs or devices. 7. Pregnant women, lactating women, or women with plans to become pregnant shortly. 8. Active stage of infection. 9. Secondary atrial fibrillation, such as combined with rheumatic heart disease, hypertrophic cardiomyopathy, etc. 10. Patients who do not agree to be enrolled or are unable to cooperate to complete the study
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What it tests

  • Pulsed field ablation
  • Radiofrequency ablation alone
  • Pulsed field ablation system
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Where

1 site
National Cardiovascular Diseases Center, Fuwai Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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