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Gut Leakage' in Dengue

Recruitingn/aAges 18 Years - anyAllUniversity of Oxford
NCT07602920 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Dengue infections are imposing an increasing global burden of disease, particularly in tropical countries such as Bangladesh. The World Health Organization (WHO) has identified Dengue virus as a priority pathogen for the development of medical counter measures because of the high risk of it causing a Public Health Emergency of Intenational Concern (PHEIC). Warning signs for severe dengue, associated with mortality, include gastrointestinal features including abdominal pain, vomiting, and diarrhoea. Multiple alterations may occur in in the gastrointestinal tract that could lead to damaging of the gastrointestinal wall and gut leakage, the translocation of gut metabolites into the bloodstream. Study team hypothesize that gut leakage initiates inflammatory processes underlying the further development of severe dengue, including features associated with plasma leakage. This study aims to in

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📋 Eligibility rules (as published)
Inclusion Criteria: Dengue participants * Participant/ legally authorised representative willing and able to give informed consent for participation in the study. * Male or Female, adults ≥18 years * Diagnosed as a case of Dengue on the basis of clinical features and positive NS1 antigen and/or IgM dengue antibody * Hospitalized in medicine or dengue ward in Chittagong Medical College Hospital. * Enrolled within 24 hours of hospitalization. Healthy participants * Participant/ legally authorised representative willing and able to give informed consent for participation in the study. * Male or Female, adults ≥18 years * Clinically healthy with no acute or chronic illness * Attendant of a dengue patient (not a patient) Exclusion Criteria: Dengue participants * Unable to provide consent or participate in follow-up procedures * Known chronic gastrointestinal (GI) disease affecting intestinal permeability (IBD, celiac disease), chronic liver disease, active chronic diarrhoea, short bowel loop syndrome, recent (\<3 months) major GI surgery. * Immunosuppression (for example chemotherapy, high-dose steroids), advanced chronic kidney disease, decompensated heart failure. * Drugs that can alter the level of biomarkers in blood like metformin, statin, probiotics, steroid within last 48 hours of hospitalization. * Pregnancy Healthy participants * Unable to provide consent * Known chronic gastrointestinal (GI) disease affecting intestinal permeability (IBD, celiac disease), chronic liver disease, active chronic diarrhoea, short bowel loop syndrome, recent (\<3 months) major GI surgery. * Immunosuppression (for example chemotherapy, high-dose steroids), advanced chronic kidney disease, decompensated heart failure. * Drugs that can alter the level of biomarkers in blood like metformin, statin, probiotics, steroid within last 48 hours of hospitalization. * Pregnancy * History of current or recent dengue or other arbo viral infection
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What it tests

  • Not listed
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Where

1 site
Department of Medicine, Chittagong Medical College
Chittagong, Bangladesh
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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