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Assessment of Venous Insufficiency and Clinical Features in Lipedema

Recruitingn/aAges 18 Years - 65 YearsFemaleSultan Abdulhamid Han Training and Research Hospi…
NCT07603076 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female participants aged 18 years or older * Clinically diagnosed lipedema according to established diagnostic criteria * Ability to provide written informed consent * Ability to complete clinical assessments and questionnaires Exclusion Criteria: * History of lower extremity venous surgery or sclerotherapy * Known peripheral arterial disease * Secondary lymphedema or other causes of lower extremity edema * Active infection, cellulitis, or inflammatory disease affecting the lower extremities * Pregnancy or postpartum period * Neurological, rheumatological, or musculoskeletal disorders significantly affecting lower extremity function * Malignancy or severe systemic disease * Inability to undergo venous Doppler ultrasonography * Inability to understand or complete study assessments and questionnaires
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What it tests

  • Venous Doppler Ultrasonography
  • Numeric Rating Scale
  • Lower Extremity Functional Scale
  • Short Form-12
  • Lower Extremity Circumference at Standardized Anatomical Landmarks (cm)
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Where

1 site
Department of Physical Medicine and Rehabilitation, Health Sciences University Sultan Abdulhamid Han Training and Research Hospital
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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