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โ† Trials
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Fertility Outcomes After Antibiotic Treatment In Women With Chronic Endometritis

Recruitingn/aAges 18 Years - 40 YearsFemaleFaculty Hospital Kralovske Vinohrady
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In plain words

What the trial is, and whether it could suit you

Chronic endometritis (CE) is a long-lasting inflammation of the lining of the uterus. Many women with CE do not have symptoms, but the condition may affect fertility, embryo implantation, and pregnancy outcomes. CE is usually diagnosed during hysteroscopy, a procedure that allows doctors to look inside the uterus and collect a small tissue sample for laboratory testing. The goal of this prospective cohort study is to learn how common CE is in women with infertility and to determine whether antibiotic treatment improves reproductive outcomes. The study will also examine whether hysteroscopic findings match laboratory-confirmed CE and whether certain findings can help doctors diagnose CE more accurately. In addition, researchers will study the types of bacteria found in the uterine lining and their possible relationship to fertility and pregnancy outcomes. The main questions the study ai

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria * Female participants aged 18-40 years. * Diagnosis of infertility (primary or secondary infertility). * Indication for diagnostic hysteroscopy with endometrial biopsy as part of infertility evaluation. * Suspected or confirmed chronic endometritis. * Ability and willingness to provide written informed consent prior to any study-related procedures. * Willingness to undergo protocol-defined antibiotic treatment. * Willingness to comply with study procedures and follow-up assessments. * Agreement to reproductive outcome monitoring following treatment, including spontaneous conception and pregnancies achieved through assisted reproductive technologies (ART). Exclusion Criteria * Age \>40 years. * Current pregnancy. * Known hypersensitivity or contraindication to tetracycline antibiotics or other study-related antibiotic therapy without a suitable alternative treatment option. * Severe systemic disease or medical condition that, in the opinion of the investigator, could interfere with study participation, safety, or interpretation of study results. * Active malignant disease requiring systemic treatment. * HIV infection or other severe immunodeficiency disorder. * Acute pelvic inflammatory disease or clinically significant active genital tract infection requiring immediate treatment. * Previous participation in this study. * Inability to undergo planned hysteroscopy or endometrial biopsy. * Inability or unwillingness to comply with study procedures or follow-up requirements. * Failure or refusal to provide written informed consent.
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What it tests

  • Not listed
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Where

2 sites
Faculty Hospital Krรกlovskรฉ Vinohrady
Prague, Czechia
PRONATAL Sanatorium
Prague, Czechia
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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