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The Effect of Different Intra-canal Medications on Postoperative Pain

RecruitingEARLY Phase 1Ages 18 Years - 40 YearsAllCairo University
NCT07603934 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients with necrotic pulps in their mandibular posterior teeth, there would be no difference in the incidence and/or severity of postoperative pain after the use of ibuprofen, nitrofurantoin, or calcium hydroxide intracanal medications. The study will evaluate postoperative pain after using either of the tested drugs as an intracanal medication amidst visits. of endodontic treatment in cases where pulp necrosis is confirmed.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with necrotic pulps. 2. Adult, healthy patients, older than 18 years old 3. Males and females. 4. Patient with the ability to understand and use pain scales. 5. Patient who accepts enroll to the study. Exclusion Criteria: 1. Patients' allergies or any other contraindication to any of the medications used. 2. Pregnant and lactating females. 3. Patients have been taking pain medication 12 hours earlier. 4. Patients who have more than one symptomatic mandibular tooth in the same quadrant. 5. Patients with contributory medical history (ASA\>II).
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What it tests

  • ibuprofen
  • Nitrofurantoin
  • Calcium Hydroxide
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Where

1 site
Faculty of Oral and Dental Medicine, Egyptian Russian University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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