Whole-Body Cryotherapy as a Non-Pharmacological Treatment to Reduce Chronic Pelvic Pain and Improve Quality of Life in People With Endometriosis

Inclusion Criteria: * Women or assigned female at birth * Aged 16 or over * Endometriosis identified at laparoscopy or imaging, performed within the last ten years * Chronic pelvic pain for more than six months * Willing to comply with the treatment * Willing to use effective contraception throughout the trial (if needed) * Willing and able to give informed consent Exclusion Criteria: * Pregnant, breastfeeding or actively trying to get pregnant * Post-menopausal (no periods for \>12 months and not taking hormonal treatments to prevent periods, or bilateral oophorectomy performed) * Previous hysterectomy with bilateral oophorectomy * Raynaud's Disease * Current treatment for malignancy * Diabetes * Known hypothyroidism * Pre-existing or current diagnosis of anaemia * Cardiovascular disease: severe hypertension (180/100, unstable angina, arrhythmia, recent (\<6months) myocardial infarction, peripheral artery disease, cardiac pacemaker, recent (\<6months) stroke or transient ischaemic attack) * Acute kidney and urinary tract diseases * Cryoglobulinemia * Previous venous thromboembolism or peripheral artery occlusive disease * Cold urticaria * Livedo reticularis * Open wounds or ulcers, large-area bacterial and viral skin infections * Uncontrolled seizure disorder * Known coagulopathy (eg von Willibrand disease, haemophilia) * Severe claustrophobia * Acute infections and fever * Intoxication (alcohol, drugs) * Signs or symptoms of cold allergy * Severe wasting diseases * Known Hepatitis B/C and/or HIV (due to Royal Mail restrictions on biospecimen postage)