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Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep

Recruitingn/aAges 18 Years - 55 YearsAllHospices Civils de Lyon
NCT07605858 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Interactions between epilepsy and sleep are numerous and bidirectional. Sleep can facilitate epileptic activity and seizures in several syndromes, while sleep deprivation increases cortical excitability and seizure susceptibility. Conversely, sleep disturbances are highly prevalent in patients with epilepsy (PWE). Using simultaneous stereoelectroencephalography (SEEG)-polysomnography, the investigators previously showed that sleep fragmentation in focal drug-resistant epilepsy is associated with both ictal and interictal epileptic activity, with increased interictal epileptiform discharges (IED) immediately before and during arousals. However, causality remains unclear, as sleep instability itself may promote epileptic discharges. Determining whether nocturnal seizures and IED directly induce awakenings is clinically important. Nocturnal epileptic activity is often considered less disab

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written informed consent obtained from study subject and ability for study subject to comply with the requirements of the study * Aged 18 to 55 years old * Diagnosis of focal temporal or frontal lobe epilepsy based on non-invasive work-up * Epilepsy is refractory to treatment, as defined by the International League Against Epilepsy 31 * Patients undergoing SEEG investigation * At least 1 frontal and 1 temporal electrode in the SEEG procedure * Patient affiliated to the French health care system Exclusion Criteria: * Multifocal epilepsy * Untreated severe obstructive sleep-apnea syndrome * Too abnormal SEEG recording interfering with sleep stage identification during the DES procedure * Severe cognitive impairment preventing full understanding and completion of the protocol * Unstable psychiatric condition * Subject participating in other interventional research with an exclusion period still in progress at pre-inclusion * Persons deprived of their liberty by a judicial or administrative decision * Adults subject to a legal protection measure (guardianship, curatorship * Persons not affiliated to a social security scheme or beneficiaries of a similar scheme
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What it tests

  • Direct Electric Stimulation (DES)
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Where

2 sites
Epilepsy Department, Duke University Hospital
Durham, United States
Service de Neurologie Fonctionnelle et d'Epileptologie Hôpital Neurologique, GHE, Hospices Civils de Lyon Hôpital Neurologique Pierre WERTHEIMER
Bron, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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