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A Single-Center Clinical Study to Evaluate the Efficacy and Safety of a Suture-Free Ophthalmic Hydrogel for Ocular Surface Tissue Adhesion

RecruitingNAAges 18 Years - 85 YearsAllSuxia Li
NCT07608367 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

When severe ocular surface lesions occur (e.g., pterygium, corneal ulcer, ocular surface burn, etc.), the currently clinically common surgical procedures such as conjunctival flap coverage, amniotic membrane transplantation, and keratoplasty are primarily fixed by suturing. However, suturing has numerous drawbacks. On the one hand, the suturing process causes additional mechanical damage to ocular surface tissues, triggers local inflammatory responses, and increases postoperative discomfort such as pain and foreign body sensation. Moreover, uneven suture tension is prone to cause conjunctival flap shrinkage or displacement, impairing the repair effect. On the other hand, postoperative suture irritation continuously activates fibroblast proliferation, leading to excessive deposition of subconjunctival collagen and the formation of dense scar tissue, which in turn compromises the stability

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with ocular surface diseases (e.g., pterygium, corneal ulcer, ocular surface burn, pseudopterygium, etc.) who need to undergo conjunctival flap adhesion, amniotic membrane transplantation, or keratoplasty. 2. Aged 18 to 85 years old at the time of informed consent (regardless of gender). 3. Able to provide written informed consent and voluntarily participate in the study. 4. No severe systemic organic diseases, such as severe heart, liver, kidney diseases, and malignant tumors. Exclusion Criteria: 1. A history of allergy to the components of the suture-free ophthalmic hydrogel (e.g., decellularized porcine corneal matrix, GelMA, etc.) or the drugs prescribed during the perioperative and postoperative observation periods (anesthetics, antibiotics, steroid preparations, etc.). 2. Patients with systemic infectious diseases (bacterial, fungal, positive for HBV, HCV and other viruses, etc.). 3. Diabetic patients with poor blood glucose control (HbA1C ≥ 8.0%). 4. Pregnant women, women who may be pregnant, or women planning to become pregnant during the clinical study. 5. Patients who have participated in other clinical trials or studies within 1 month before obtaining informed consent. 6. Other patients deemed unsuitable for the clinical study due to comorbidities.
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What it tests

  • Suture-Free Ophthalmic Hydrogel for Ocular Surface Surgery
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Where

1 site
Shandong Eye Hospital
Jinan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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