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guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing

RecruitingNAAges 18 Years - anyAllColumbia University
NCT07610590 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study looks at whether genome sequencing should be used more routinely during pregnancy, even when ultrasounds look normal. Genome sequencing can examine nearly all of a baby's genes and may find genetic conditions that standard tests do not detect. Researchers will compare this test with current prenatal testing to see if it provides helpful information for families and doctors. The study will also explore how parents decide what kinds of genetic information they want to receive and how this information affects their experience during pregnancy. The goal is to understand whether genome sequencing can be used in a way that is helpful, responsible, and supportive for families in the future.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient planned chorionic villus sampling (CVS) or amniocentesis in the absence of major fetal structural anomalies (minor anomalies are eligible, the HPO (Human Phenotype Ontology) will not be used by the analyst) * Certified genetic counselor involved in care Exclusion Criteria: * A major structural anomaly * Maternal or paternal age less than 18 years old * Parental unwillingness to participate in 1 year of postnatal follow-up * Language barrier (non-English or Spanish speaking)
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What it tests

  • Genome Sequencing (GS)
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Where

3 sites
Boston Childrens Hospital
Boston, United States
New York Genome Center
New York, United States
Columbia University Irving Medical Center (CUIMC)
New York, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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