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Sevoflurane vs Propofol Anesthesia in Obese Patients Undergoing Lumbar Surgery

RecruitingNAAges 18 Years - 65 YearsAllAtaturk University
NCT07611240 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized, single-center, single-masked clinical trial aims to compare the immunomodulatory effects of sevoflurane-based inhalational anesthesia and propofol-based total intravenous anesthesia in obese patients undergoing elective lumbar instrumentation surgery. Seventy patients will be randomized into two groups: a propofol group and a sevoflurane group. Blood samples will be collected preoperatively, at postoperative 6 hours, and at postoperative 24 hours. Pentraxin-3 and serum amyloid A levels will be evaluated as primary inflammatory biomarkers together with IL-6, TNF-α, CRP, glucose, and complete blood count parameters.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 18 and 65 years * Patients scheduled for elective lumbar instrumentation surgery * Body mass index between 30 and 34.9 kg/m² * Patients who provided written informed consent Exclusion Criteria: * Known allergy to inhalational or intravenous anesthetic agents * Acute or chronic infectious disease * Autoimmune disease or immunodeficiency * Surgery within the last 3 months * Chronic anti-inflammatory or immunomodulatory drug use * Morbid obesity, defined as BMI \>35 kg/m² * History of malignancy or active cancer treatment * Renal failure, defined as GFR \<60 mL/min * Liver failure, defined as AST or ALT greater than 2 times the upper limit of normal * Diabetes mellitus, metabolic syndrome, or insulin resistance * Pregnancy or lactation * Neurological disease, including epilepsy, multiple sclerosis, or Parkinson's disease * Alcohol or substance abuse * Inability to comply with the study protocol or provide informed consent * Known allergy to study drugs (propofol, sevoflurane, remifentanil) * Emergency surgery
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What it tests

  • Propofol (Astra-Zeneca)
  • Sevoflurane
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Where

1 site
Ataturk University
Erzurum, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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