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Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis

Recruitingn/aAges 18 Years - anyAllFirst Affiliated Hospital of Wannan Medical Colle…
NCT07613632 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with end-stage renal disease (ESRD) often require arteriovenous grafts (AVG) for hemodialysis. AVG thrombosis is a common complication, usually managed by percutaneous transluminal angioplasty (PTA) to restore blood flow. PTA achieves patency by balloon-mediated compression and fragmentation of thrombus. Small thrombus fragments may enter the venous circulation and cause transient pulmonary microembolism, leading to ventilation-perfusion (V/Q) mismatch. This study uses electrical impedance tomography (EIT) to noninvasively monitor short-term changes in regional ventilation and perfusion during and after PTA, exploring the immediate pulmonary physiological consequences of thrombus fragmentation and revascularization in dialysis patients.

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📋 Eligibility rules (as published)
Inclusion Criteria 1. Age ≥ 18 years. 2. Diagnosis of end-stage renal disease receiving maintenance hemodialysis. 3. Documented AVG thrombosis requiring PTA. 4. Able to cooperate and tolerate EIT monitoring. 5. Provided written informed consent. Exclusion Criteria 1. Severe respiratory failure incompatible with supine position. 2. Thoracic skin condition or deformity preventing EIT electrode placement. 3. Acute pulmonary embolism or acute pulmonary edema before procedure. 4. NYHA Class IV heart failure or hemodynamic instability. 5. Pregnancy or breastfeeding. 6. Any other circumstance judged unsuitable by investigator.
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What it tests

  • Electrical Impedance Tomography (EIT) Monitoring
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Where

1 site
The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)
Wuhu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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