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Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease

RecruitingNAAges 18 Years - anyAllMassachusetts General Hospital
NCT07613840 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine whether a personalised blood clot prevention plan is more effective than standard treatment in adults with peripheral artery disease (PAD) who have undergone a procedure to restore blood flow to their legs. The main questions it aims to answer are: * Does the personalized plan lower the rate of blood clots in the treated leg one year after the procedure? * Does the personalized plan lower rates of amputation, repeat procedures, bleeding, and death compared to standard treatment? Researchers will compare the personalized TARGET plan which uses a blood test to tailor each person's blood clot prevention medication to the standard treatment to see if the personalized approach works better. Participants will: * Be randomly assigned to either the personalized TARGET plan or standard treatment after their procedure * Have blood tests at 1 wee

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with a named arterial extremity injury or named vessel revascularization for atherosclerosis requiring open and/or closed revascularization. * Patients at the age of 18 or older Exclusion Criteria: * Patients who are younger than 18 years old * Known pregnancy (females of childbearing potential will have a pregnancy test prior to surgery as per standard of care) * Prisoners, defined as those who have been directly admitted from a correctional facility. * No atherosclerosis * Subject has active stomach ulcers * Subject has severe hepatic impairment * Subject has a recent history of intracranial hemorrhage. If the patient has a history of cerebral hemorrhage with no new central nervous system disease of \>1 year, the study team will consult with the
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What it tests

  • Aspirin
  • Clopidogrel
  • Ticagrelor
  • Rivaroxaban
  • Thromboelastography with Platelet Mapping
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Where

2 sites
Massachusetts General Hospital
Boston, United States
Salem Hospital (Mass General Brigham)
Salem, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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