Clonal Hematopoiesis of Indeterminate Potential and Infarct Severity in ST-Elevation Myocardial Infarction

Inclusion Criteria: * Diagnosis of first acute ST-elevation myocardial infarction according to current European Society of Cardiology guidelines * Symptoms consistent with ST-elevation myocardial infarction lasting more than 30 minutes and less than 12 hours before primary percutaneous coronary intervention * Treatment with primary percutaneous coronary intervention * Age 18 to 75 years * Written informed consent Exclusion Criteria: * Prior myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention * Persistent hemodynamic instability, Killip class greater than 2 including cardiogenic shock, or resuscitated cardiac arrest not allowing cardiac magnetic resonance imaging * Known active or prior malignancy, including hematologic malignancies or myelodysplastic syndromes * Prior oncologic treatment with chemotherapy, radiotherapy, or radioisotopes * Abnormal baseline complete blood count with clinically significant cytopenia, defined as leukocytes less than 3.0 x 10\^9/L, platelets less than 100 x 10\^9/L, or hemoglobin less than 10 g/dL * Chronic viral infection associated with systemic inflammation * Active autoimmune disease or chronic systemic inflammatory disorder * Chronic kidney disease with creatinine clearance less than 30 mL/min/1.73 m2 * Contraindication to cardiac magnetic resonance imaging * Pre-ST-elevation myocardial infarction life expectancy of less than 1 year * Participation in an interventional trial * Limited possibility to attend follow-up examinations, for example residence abroad * Pregnancy