🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

AP-NOSES: A Prospective Multicentre Registry of Natural Orifice Specimen Extraction in Minimally Invasive Colorectal Surgery

Recruitingn/aAges 21 Years - anyAllSingapore General Hospital
NCT07615036 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Natural orifice specimen extraction (NOSE) is a minimally invasive colorectal surgical technique in which the surgical specimen is removed through a natural orifice, including transanal or transvaginal routes, thereby avoiding an abdominal extraction incision. Observational studies suggest that NOSE may reduce wound-related morbidity and improve postoperative recovery, but prospective multicenter data evaluating long-term outcomes remain limited. AP-NOSES is a prospective, multicenter observational registry evaluating clinical, patient-reported, and long-term wound outcomes following minimally invasive colorectal surgery with NOSE or transabdominal specimen extraction. The primary objective is to compare time to incisional hernia within 24 months between NOSE-eligible patients undergoing planned NOSE extraction and NOSE-eligible patients undergoing planned transabdominal extraction. Se

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Age 21 years or older * Elective minimally invasive colorectal resection (laparoscopic or robotic intent) * Planned intact specimen extraction * Eligible for natural orifice specimen extraction (NOSE) or transabdominal specimen extraction according to study protocol * Ability to provide informed consent Exclusion Criteria: * Emergency colorectal surgery * Planned transanal total mesorectal excision (TaTME) * Planned ultralow anterior resection with planned anastomosis 3 cm or less from the anal verge * Planned abdominoperineal resection (APR) * Planned permanent end stoma without restoration of intestinal continuity * Planned multivisceral resection * Generalized peritonitis or uncontrolled intra-abdominal sepsis * Pregnancy * Pre-existing ventral or incisional hernia at the planned extraction site * Planned specimen extraction through a prior laparotomy incision containing mesh * Fixed distal obstruction, severe pelvic stenosis, or other anatomical constraint precluding intact specimen extraction
💊

What it tests

  • Natural Orifice Specimen Extraction
  • Transabdominal Specimen Extraction
📍

Where

1 site
Singapore General Hospital
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy