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The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine

Recruitingn/aAges 18 Years - 75 YearsAllIstituto per la Ricerca e l'Innovazione Biomedica
NCT07617441 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic migraine is a disabling neurovascular disorder and one of the leading causes of years lived with disability worldwide. Population-based studies report a worrying level of resistance to currently available treatments in clinical practice. For this reason, the clinical and scientific community is increasingly investigating new therapeutic approaches aimed at reducing the burden of symptoms and improving patients' quality of life. Among the alternative therapeutic approaches explored in migraine research, the placebo effect has emerged as a potentially important mechanism. However, the duration and intensity of its beneficial effects on migraine symptoms are still poorly understood. In particular, there is a need to identify biological and clinical markers that may predict which patients are more likely to benefit from placebo-related mechanisms. One of the most promising factors

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📋 Eligibility rules (as published)
Inclusion Criteria for Non-Responsive Chronic Migraine subjects: * adults aged ≥ 18 years and ≤ 75 years; * diagnosis of non-responsive chronic migraine (NRCM) according to ICHD-3 beta criteria; * presence of at least 8 migraine days per month associated with disability (MIDAS ≥ 11), and insufficient response after 6 weeks or inability to tolerate at least three previously prescribed migraine preventive agents, i.e., resistance to standard therapy for at least 6 weeks; * signed informed consent. Inclusion Criteria for healthy subjects are: * adults aged ≥ 18 years and not older than 75 years; * absence of a diagnosis of NRCM according to ICHD3beta or other relevant -neurological disorders as assessed during the medical history taken at the headache center; * signed informed consent. Exclusion Criteria: * older than 75 years; * children * pregnant or breastfeeding women; * history of alcohol or substance abuse; * affected by concomitant neurological, cardiovascular, or cerebrovascular diseases; * liver disease or kidney disease; * psychiatric disorders (psychosis, major depression, bipolar disorder). * diagnosis or history of migraine (for healthy subjects).
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What it tests

  • Not listed
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Where

1 site
Renato Dulbecco University Hospital
Catanzaro, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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