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Study of DCC-2618 in Patients With GIST After at Least 3 Prior Treatments

RecruitingPhase 1Ages 18 Years - anyAllOno Pharmaceutical Co., Ltd.
NCT07618377 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To evaluate the safety of DCC-2618 in patients with unresectable, metastatic, or recurrent gastrointestinal stromal tumor (GIST) who have received three or more prior therapies

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Participants with a histologically confirmed diagnosis of GIST. 2. Participants who are refractory or intolerant to treatment with at least imatinib, sunitinib, and regorafenib. 3. Participants with at least one measurable lesion per the modified Response Evaluation Criteria in Solid Tumors (mRECIST) within 28 days prior to the first administration of the investigational product. 4. Participants with an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1. Exclusion Criteria: 1. Participants with a concomitant or prior history of severe hypersensitivity reactions to other tyrosine kinase inhibitors. 2. Participants with uncontrolled diabetes mellitus. 3. Participants with a systemic infection requiring treatment.
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What it tests

  • DCC-2618
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Where

2 sites
National Cancer Center Hospital East
Kashiwa, Japan
National Cancer Center Hospital
Tokyo, Japan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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