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Nociception Level Index After Brachial Plexus Block In Upper Extremity Surgery

Recruitingn/aAges 18 Years - anyAllCarmel Medical Center
NCT07620002 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The present prospective within-subject observational study will evaluate whether unilateral brachial plexus block (BPB) induces measurable lateralized autonomic modulation, assesses using bilateral Nociception Level (NoL) monitoring during standardized intraoperative stimuli under general anesthesia. Regional anesthesia efficacy is traditionally assessed through sensory and motor examination. However, objective physiologic markers reflecting sympathetic modulation remain limited. Forty five adults undergoing upper extremity surgery with BPB and general anesthesia, bilateral NoL monitoring will be performed during local anesthetic injection, endotracheal intubation, and nasogastric tube placement. The primary aim to investigate whether the brachial plexus block induces unilateral modulation of post-operative nervous system activity, assessed by inter-limb differences in NoL values during

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 * Upper extremity surgery * Provision of signed and dated informed consent forms Exclusion Criteria: * Pregnant women * Known allergic reaction to bupivacaine or other anesthetic medicine: Midazolam, Fentanyl, Propofol, Rocuronium, Remifentanil, Sevoflurane) * Known coagulopathy resulting in bleeding tendency * Thrombocytopenia * Abnormal laboratory coagulation tests in the previous week = Anticoagulation therapy Participation in other study
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What it tests

  • Not listed
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Where

1 site
Carmel medical center
Haifa, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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