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GnRH for Luteal Support - Mechanism of Action

Recruitingn/aAges 18 Years - 45 YearsFemaleHeli Alexandroni
NCT07620067 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective observational study will include women undergoing IVF treatment with a GnRH antagonist protocol and fresh embryo transfer at the IVF unit of Shaare Zedek Medical Center. Patients will undergo controlled ovarian stimulation followed by ovulation triggering with hCG, GnRH agonist, or dual trigger according to OHSS risk. After oocyte retrieval and fertilization by IVF/ICSI, embryos will be cultured and transferred. Luteal phase support will consist of either intranasal GnRH agonist (Synarel) or vaginal progesterone. Blood and follicular fluid samples will be collected at predefined time points to assess hormonal, inflammatory, and angiogenic markers, including LH, FSH, estradiol, progesterone, IL-6, IL-8, VEGF, PEDF, and relaxin.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women included in the study will be 18-45 years old * undergoing IVF treatments due to ovulation disorder, mechanical factor, primary ovarian insufficiency, or male infertility. * All women will be at their first to the third cycle of treatment * women will undergo a fresh ET. Exclusion Criteria: * repeated implantation failure (more than 3 cycles of good quality ET without implantation) * moderate-severe endometriosis * hydrosalpinx * fibroid uterus * BMI more than 35 or less than 19 * women with hypogonadotropic hypogonadism * PGT of embryos * use of surgical techniques for sperm retrieval * preference of the long GnRH-agonist protocol * women with rhinitis or nasal congestion.
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What it tests

  • GnRH agonist
  • Progesterone
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Where

1 site
Shaare Zedek Medical Center
Jerusalem, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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