Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Inclusion Criteria: * Subject willing and able to read, understand and sign an informed consent * Diagnosis of mild to moderate severity of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome * Patients diagnosed with CFS for more than 1 years * Stable psychological and pharmacological treatment for more than three months prior to inclusion Exclusion Criteria: 1. Inability to attend scheduled clinic visits and/or comply with the study protocol 2. Severe and very severe cases of ME/CFS 3. History or diagnosis of, brain tumors, brain surgery, epilepsy, neurodegenerative diseases 4. Active malignancy 5. Substance use at baseline, except for prescribed cannabis if vaporized or taken PO as tincture 6. Active smokers 7. Chronic heart failure with ejection fraction of 30 or less 8. Chest pathology incompatible with pressure changes (including active asthma or COPD) 9. Ear or Sinus pathology incompatible with pressure changes (above 3 otolaryngologist visits a year) 10. Pregnancy 11. An inability to perform an awake brain MRI 12. An inability to perform Neurotrax 13. Participation in another medical study 14. HBOT for any reason prior to study enrolment