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Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health

RecruitingNAAges 65 Years - anyAllSouth Dakota State University
NCT07623785 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

his study investigates whether eating lean beef every day can help support brain health and healthy aging in older adults. As people age, protecting memory and cognitive function becomes increasingly important. Lean beef is a rich source of essential nutrients-such as vitamin B12, iron, zinc, and creatine-that are known to support brain function. However, the direct biological effects of a beef-rich diet on brain health markers are not fully understood. In this study, researchers will recruit 20 generally healthy older adults (aged 65 and older) to participate in a dietary feeding trial. Participants will complete two separate 2-week dietary phases. During one phase, participants will consume 5.5 ounces (156 grams) of provided lean beef daily. During the other phase, they will consume an iso-caloric, protein-matched, non-beef control food daily. A two-week "washout" period, where partic

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📋 Eligibility rules (as published)
Inclusion Criteria: Adults aged 65 years and older. Generally healthy with no acute illnesses. Fluent in English. Willing to consume lean beef and dairy products (cottage cheese and whey protein) daily during the intervention phases. Willing to maintain current, habitual diet, physical activity levels, and body weight throughout the study. Willing to fast for 12 hours prior to clinical visits and provide blood, urine, stool, and saliva samples. Exclusion Criteria: Diagnosed with Alzheimer's disease, Parkinson's disease, or other severe cognitive disorders. History of gastrointestinal diseases (e.g., Crohn's disease, celiac disease) or major gastrointestinal surgery. Uncontrolled diabetes, severe liver or kidney disease, or a recent cardiovascular event (within the past 6 months). Allergies or severe intolerances to beef or dairy, or adherence to a strict vegetarian or vegan diet. Body weight fluctuation of \>5% within the past 3 months. Use of systemic antibiotics within the 2 months prior to baseline. Current heavy smoking or excessive alcohol consumption.
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What it tests

  • Lean Beef
  • Non-Beef Control
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Where

1 site
South Dakota State University
Brookings, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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